CCR2 (ccr2_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CCR2
GENE
CCR2 (CMKBR2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, CD192
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
L
|
S
|
T
|
S
|
R
|
S
|
R
|
F
|
I
|
10 |
R
|
N
|
T
|
N
|
E
|
S
|
G
|
E
|
E
|
V
|
20 |
T
|
T
|
F
|
F
|
D
|
Y
|
D
|
Y
|
G
|
A
|
30 |
TM1 | |||||||||
P
|
C
|
H
|
K
|
F
|
D
|
V
|
K
|
Q
|
I
|
40 |
G
|
A
|
Q
|
L
|
L
|
P
|
P
|
L
|
Y
|
S
|
50 |
L
|
V
|
F
|
I
|
F
|
G
|
F
|
V
|
G
|
N
|
60 |
M
|
L
|
V
|
V
|
L
|
I
|
L
|
I
|
N
|
C
|
70 |
ICL1 | TM2 | ||||||||
K
|
K
|
L
|
K
|
C
|
L
|
T
|
D
|
I
|
Y
|
80 |
L
|
L
|
N
|
L
|
A
|
I
|
S
|
D
|
L
|
L
|
90 |
F
|
L
|
I
|
T
|
L
|
P
|
L
|
W
|
A
|
H
|
100 |
ECL1 | |||||||||
S
|
A
|
A
|
N
|
E
|
W
|
V
|
F
|
G
|
N
|
110 |
TM3 | |||||||||
A
|
M
|
C
|
K
|
L
|
F
|
T
|
G
|
L
|
Y
|
120 |
H
|
I
|
G
|
Y
|
F
|
G
|
G
|
I
|
F
|
F
|
130 |
I
|
I
|
L
|
L
|
T
|
I
|
D
|
R
|
Y
|
L
|
140 |
ICL2 | |||||||||
A
|
I
|
V
|
H
|
A
|
V
|
F
|
A
|
L
|
K
|
150 |
TM4 | |||||||||
A
|
R
|
T
|
V
|
T
|
F
|
G
|
V
|
V
|
T
|
160 |
S
|
V
|
I
|
T
|
W
|
L
|
V
|
A
|
V
|
F
|
170 |
A
|
S
|
V
|
P
|
G
|
I
|
I
|
F
|
T
|
K
|
180 |
ECL2 | |||||||||
C
|
Q
|
K
|
E
|
D
|
S
|
V
|
Y
|
V
|
C
|
190 |
TM5 | |||||||||
G
|
P
|
Y
|
F
|
P
|
R
|
G
|
W
|
N
|
N
|
200 |
F
|
H
|
T
|
I
|
M
|
R
|
N
|
I
|
L
|
G
|
210 |
L
|
V
|
L
|
P
|
L
|
L
|
I
|
M
|
V
|
I
|
220 |
C
|
Y
|
S
|
G
|
I
|
L
|
K
|
T
|
L
|
L
|
230 |
ICL3 | TM6 | ||||||||
R
|
C
|
R
|
N
|
E
|
K
|
K
|
R
|
H
|
R
|
240 |
A
|
V
|
R
|
V
|
I
|
F
|
T
|
I
|
M
|
I
|
250 |
V
|
Y
|
F
|
L
|
F
|
W
|
T
|
P
|
Y
|
N
|
260 |
I
|
V
|
I
|
L
|
L
|
N
|
T
|
F
|
Q
|
E
|
270 |
ECL3 | TM7 | ||||||||
F
|
F
|
G
|
L
|
S
|
N
|
C
|
E
|
S
|
T
|
280 |
S
|
Q
|
L
|
D
|
Q
|
A
|
T
|
Q
|
V
|
T
|
290 |
E
|
T
|
L
|
G
|
M
|
T
|
H
|
C
|
C
|
I
|
300 |
H8 | |||||||||
N
|
P
|
I
|
I
|
Y
|
A
|
F
|
V
|
G
|
E
|
310 |
K
|
F
|
R
|
S
|
L
|
F
|
H
|
I
|
A
|
L
|
320 |
C-term | |||||||||
G
|
C
|
R
|
I
|
A
|
P
|
L
|
Q
|
K
|
P
|
330 |
V
|
C
|
G
|
G
|
P
|
G
|
V
|
R
|
P
|
G
|
340 |
K
|
N
|
V
|
K
|
V
|
T
|
T
|
Q
|
G
|
L
|
350 |
L
|
D
|
G
|
R
|
G
|
K
|
G
|
K
|
S
|
I
|
360 |
G
|
R
|
A
|
P
|
E
|
A
|
S
|
L
|
Q
|
D
|
370 |
K
|
E
|
G
|
A
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL7, CCL11, CCL16, CCL26, CCL24, CCL13, CCL8, CCL2
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page